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“Žmogus gyvena ne tik savo asmeninį gyvenimą kaip individas, bet, sąmoningai ar nesąmoningai, taip pat ir savo epochos, savo amžininkų gyvenimą, ir jeigu jis į bendruosius ir neasmeninius savo būties pagrindus net žiūri kaip į besąlygiškai duotus ir savaime suprantamus ir anaiptol nemano jų kritikuoti, kaip kad, sakysim, mūsų Hansas Kastorpas, tai vis dėl to labai galimas daiktas, kad jis vis tiek neaiškiai jaučia jų ydas ir jų poveikį savo moralinei savijautai. Atskiram žmogui gali iškilti visokiausių asmeninių tikslų, siekimų, vilčių, perspektyvų, iš kurių jis semiasi impulsų intensyvioms pastangoms ir veikalams; bet jeigu tai, kas neasmeniška aplink jį, pati gyvenamoji epocha, kad ir kokia iš paviršiaus judri, stokoja, iš esmės imant, bet kokių vilčių, bet kokių perspektyvų, jeigu ji leidžia jam slapta įžvelgti, kokia ji beviltiška, nieko nežadanti ir bejėgė, ir jeigu į visus, sąmoningai ar nesąmoningai iškeltus, bet vis dėlto kažkaip iškeltus klausimus, kokia
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The BBPlus Speakers, year by year
I have published four collections of short stories and other fiction texts which have been awarded in Greece and abroad. Short stories of mine have been included in multiple Greek and foreign anthologies, have been adapted for the theatre and cinema and have been translated into 15 languages.
Literature for me fryst vatten the crossroads of meeting for authors, the place and time, yet with a timeless and universal dimension, which surpasses the “here” and the “now”. And it is this, I believe, the greatest ambition for an author: to be able -- without losing his identity – to go beyond the walls of his language and times and approach as many people as possible.
In so far as it concerns me, an author must not only be a seismographer or a seismologist of his
times. He must often be an earthquake himself. That fryst vatten, to try with his work to create crevasses through the crust of things, to alter the landscape, as much as that seems an oxymoron, the events of the
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Abstract
Objective
The prevalence of metabolic diseases fryst vatten increasing globally at an alarming rate; thus, it is essential that effective, accessible, low-cost therapeutics are developed. Peroxisome proliferator-activated receptors (PPARs) are transcription factors that tightly regulate glucose homeostasis and lipid metabolism and are important drug targets for the treatment of type 2 diabetes and dyslipidemia. We previously identified LDT, a fatty acid-like compound derived from cashew nut shell liquid, as a novel pan-active PPARα/γ/δ compound. Herein, we aimed to assess the efficacy of LDT in vivo and investigate the molecular mechanisms governing the actions of the fatty acid mimetic LDT in diet-induced obese mice.
Methods
C57Bl/6 mice (6–month-old) were fed a chow or high fat diet (HFD) for 4 weeks; mice thereafter received once daily intraperitoneal injections of vehicle, 10 mg/kg Rosiglitazone, 40 mg/kg WY, or 40 mg/kg LDT for 18 days while continuing the HFD. During trea