Zucai suo biography
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Biosketch
Dr. Zucai Suo received both his B.S. in chemistry and M.S. in physical chemistry from Fudan University in Shanghai, China. He then worked as a semiconductor scientist to develop infrared detectors for meteorological satellites in Shanghai Institute of Applied Physics, kinesisk Academy of Sciences. Subsequently, Dr. Suo moved to USA to study and obtained his Ph.D. in biological chemistry in the laboratory of Kenneth A. Johnson at Pennsylvania State University. After graduate studies, Dr. Suo became a Jane Coffin Childs Memorial Fund Postdoctoral Fellow for two years in the laboratory of Christopher T. Walsh at Harvard Medical School. Subsequently, he worked as a senior biochemist at Eli Lilly to develop anti-hepatitis C drugs. From 2001 to 2018, Dr. Suo was Assistant, Associate and Full Professor at the Department of Biochemistry, The Ohio State University. In the summer of 2018, Dr. Suo moved his laboratory to Florida State University College of medicin. Dr. Suo has serve
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Published in sista edited form as: Chem Res Toxicol. 2016 Dec 8;30(1):260–269. doi: 10.1021/acs.chemrestox.6b00342
Abstract
Innovative advances in X-ray crystallography and single-molecule biophysics have yielded unprecedented insight into the mechanisms of DNA lesion bypass and damage repair. Time-dependent X-ray crystallography has been successfully applied to view the bypass of 8-oxo-7,8-dihydro-2′-deoxyguanine (8-oxoG), a major oxidative DNA lesion, and the incorporation of the triphosphate form, 8-oxo-dGTP, catalyzed by human DNA polymerase β. Significant findings of these studies are highlighted here, and their contributions to the current mechanistic understanding of mutagenic translesion DNA synthesis (TLS) and base excision repair are discussed. In addition, single-molecule Forster resonance energy transfer (smFRET) techniques have recently been adapted to investigate nucleotide binding and incorporation opposite un
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The Suo Research Lab
Eminent Professor
Dorian and John Blackmon Chair in Biomedical Science
Department of Biomedical Sciences
College of Medicine
Florida State University
Tallahassee, FL 32306-4300
Telephone: 850-645-2501
Email:zucai.suo@med.fsu.edu
Available Positions
Postdoctoral Positions in Exosome-Based Drug Discovery:
Two postdoctoral positions are available immediately in a drug discovery and enzymology laboratory to develop new therapies based on drug delivery via either liposomes or extracellular vesicles (exosomes) secreted by human mesenchymal stem cells. Background in extracellular vesicles, molecular biology, drug screening, cell-based assays, protein purification, recombinant DNA techniques, and biochemistry is preferred. An important criterion for selection will be the ability of the desired individuals to pursue independent research in an active multi-disciplinary setting. Any interested candidate should send a CV, and a statement