Madina kochenova biography of martin

  • Martin Parker and John Jaworski with an Introduction by Dr. Colin S Interviewed by host Madina Kochenova of Russia Today on RT. Arranged by RT.
  • This preprint is open for discussion and under review for Atmospheric Chemistry and Physics (ACP).
  • Using Xenopus egg extracts, we show that the TOP2 poisons etoposide and doxorubicin both inhibit DNA replication through different mechanisms.

    • •

    Test / Sample List of Publications

  • Discovery of Human PIM Kinase Inhibitors as a Class of Anthelmintic Drugs to Treat Intestinal Nematode Infections.

    Banas V, Elfawal MA, Rosa BA, Mahoney M, Kauffman J, Goetz E, Chen P, Aroian RV, Mitreva M, Janetka JW.

    ACS Infect Dis. 2025 Jan 19. doi: 10.1021/acsinfecdis.4c00864. Online ahead of print.
    PMID: 39828994

    Continue reading →

  • Das M, Hile SE, Brewster J, Boer JL, Bezalel-Buch R, Guo Q, Yang W, Burgers PM, Eckert KA, Freudenreich CH. “DNA polymerase zeta can efficiently replicate structures formed by AT/TA repeat sequences and prevent their deletion. ” Nucleic Acids Res. 2024 Dec 27:gkae1254. doi: 10.1093/nar/gkae1254. Online ahead of print. PMID: 39727171(Abstract)

    Continue reading →

  • Henze E, Ehrlich JJ, Robertson JL, Gelsleichter E, Kawate T. “The C-terminal activating domain promotes pannexin 1 channel opening.” Proc Natl Acad Sci U S A. 2024 Dec 17;121(51):e2411898121. doi: 10.1073/pn

    •

    Chiral proofreader recruited from Archaea relieves anaerobic stress associated with translation machinery in land plants.

    Abstract

    Streptophyte algae emerged as a land plant with adaptations that eventually led to terrestrialization. Land plants encounter a range of biotic and abiotic stresses that elicit anaerobic stress responses. Here, we show that acetaldehyde, a toxic metabolite of anaerobic stress, targets and generates ethyl adducts on aminoacyl-tRNA, a central component of the translation machinery. However, elongation factor thermo unstable (EF-Tu) safeguards l-aminoacyl-tRNA, but not d-aminoacyl-tRNA, from being modified by acetaldehyde. We identified a unique activity of archaeal-derived chiral proofreading module, d-aminoacyl-tRNA deacylase 2 (DTD2), that removes N-ethyl adducts formed on d-aminoacyl-tRNAs (NEDATs). Thus, the study provides the molecular basis of ethanol and acetaldehyde hypersensitivity in DTD2 knockout plants. We uncovered an important gene transf

    •

    NOMAD, an Integrated Suite of Three Spectrometers for the ExoMars Trace Gas Mission: Technical Description, Science Objectives and Expected Performance

    The scientific objectives of the NOMAD instrument can be categorized in three inter-related domains. These are compliant with and follow closely the science objectives of the TGO mission that were presented in Zurek et al. (2011). NOMAD will first of all gather information on a wide urval of trace gases and therefore help to better constrain the chemical composition of the Martian atmosphere. Then, based on these observations, climatologies of different species as well as of dust and clouds will be developed or improved and extended. Finally, the large new data sets comprising vertical profiles and mapping not only of trace gases, but also of the main constituents, temperature and dust/clouds, will be analyzed by cross-correlations and in combination with atmospheric models. This will allow for a more global understanding of the

  • madina kochenova biography of martin