Vroon sharma biography of martin
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Published in sista edited form as: Brain Behav Immun. 2020 Oct 27;91:418–428. doi: 10.1016/j.bbi.2020.10.022
Abstract
More than a quarter of veterans of the 1990–1991 Persian Gulf War suffer from Gulf War Illness (GWI), a chronic, multi-symptom illness that commonly includes musculoskeletal pain. Exposure to a range of toxic chemicals, including sarin nerve agent, are a suspected root cause of GWI. Moreover, such chemical exposures induce a neuroinflammatory response in rodents, which has been linked to several GWI symptoms in rodents and veterans with GWI. To date, a neuroinflammatory basis for pain associated with GWI has not been investigated. Here, we evaluated development of nociceptive hypersensitivity in a model of GWI. Male Sprague Dawley rats were treated with corticosterone in the drinking water for 7 days, to mimic high physiological stress, followed by a single injection of the sarin nerve agent surrogate, diisoprop
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Nonhuman primate genetic models for the study of rare diseases
- Review
- Open access
- Published:
- Eric J. VallenderORCID: orcid.org/0000-0003-3506-05401,2,
- Charlotte E. Hotchkiss3,4,
- Anne D. Lewis5,6,
- Jeffrey Rogers7,8,
- Joshua A. Stern9,10,
- Samuel M. Peterson5,6,
- Betsy Ferguson5,6 &
- …
- Ken Sayers11,12
Orphanet Journal of Rare Diseasesvolume 18, Article number: 20 (2023) Cite this article
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Abstract
Pre-clinical research and development relies heavily upon translationally valid models of disease. A major difficulty in understanding the biology of, and developing treatments for, rare disease is the lack of djur models. It is important that these models not only recapitulate the presentation of the disease in humans, but also that they share functionally equivalent underlying genetic causes. Nonhuman primates share physiological, anatomical, and behavioral similarities with humans re
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